کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5851869 | 1561793 | 2013 | 6 صفحه PDF | دانلود رایگان |
We conducted a 90-day feeding study to investigate subchronic toxicity of rice hull fiber. Sprague Dawley rats were randomly divided into four groups; each received a diet containing 0%, 2.5%, 3.75% and 5.0% (w/w) rice hull fiber for 90Â days. Clinical observations were carried out daily, with weekly measurements of body weight and food consumption. We performed ophthalmic and histological examinations at termination. Blood and urine samples were collected to measure hematology and clinical chemistry parameters. No mortality, ophthalmic abnormalities, or adverse treatment-related effects were seen during clinical observations, hematological tests, or analyses of urine. Macroscopic or microscopic examinations of organs revealed no treatment related abnormalities. The only treatment related significant changes were reduced concentrations of fasting blood glucose (up to 17.6%) and cholesterol (up to 22.0%), typical benefits of dietary fiber, in males treated with 3.75 and 5% rice hull fiber. The no-observed-adverse-effect-level (NOAEL) for rice hull fiber was 5.0% for both genders (females, 3.80Â g/kg body weight/day; males, 4.11Â g/kg body weight/day).
⺠Rice fiber (RF) might have an effect on the animal body weight in some degree. ⺠No adverse effects were observed in rats fed diets with up to 5.0% RF for 13 weeks. ⺠The NOAEL of RF is 3.80 and 4.11 g/kg/day to female and male rats, respectively.
Journal: Food and Chemical Toxicology - Volume 51, January 2013, Pages 137-142