Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high-sugar, high-fat diet and its underlying mechanism

► Cinnamon polyphenols (CPS) is a potential agent for the treatment of diabetes. ► CPS exerts the hypoglycemic and hypolipidemic effects. ► CPS can down-regulate iNOS and NF-κB expressions in pancreatic tissue. ► CPS effectively mediates restoration of pancreatic cell injure. ► CPS therapy attenuates cytotoxic effects in pancreatic cells.