Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo

► LPS is inflammatory mediator for vascular inflammation. ► Rutin inhibited LPS induced hyperpermeability in vitro and in vivo. ► Rutin inhibited LPS-mediated inflammatory responses. ► Rutin inhibited TNF-α mediated hyperpermeability. ► Rutin also suppressed the activation of NF-κB and production of TNF-α.