Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells

► SG was isolated and purified from the brown alga Sargassum siliquastrum as a novel anti- osteoclastogenic substance. ► We tested whether SG could inhibit IL-1β-induced osteoclastogenic factors in human osteoblast MG-63 cells. ► We also examined the role of SG on NF-κB and MAPK signaling. ► SG inhibited the production of osteoclastogenic factors and the phosphorylation of MAPK and NF-κB in MG-63 cells. ► SG regulates the expression of osteoclastogenic factors via suppression of NF-κB activation and MAPK phosphorylation.