Di (2-ethylhexyl) phthalate modulates cholinergic mini-presynaptic transmission of projection neurons in Drosophila antennal lobe

► DEHP, a common plasticizer, has been a major safety problem to human health. ► Electrophysiology properties of PN were examined to show the neurotoxicity of DEHP. ► DEHP could alter the neuron properties by inhibiting the calcium channel activity. ► Drosophila can be an ideal neural circuit model used to detect the effects of DEHP.