The natural outcome of melamine-induced bladder stones with bladder epithelial hyperplasia after the withdrawal of melamine in mice

► Three ideal dual-models of cystolith and BEH were established in BALB/c mice. ► The natural outcome of the stone and BEH after melamine withdrawn was explored. ► The stone and BEH have the natural property of rapid development and regression. ► Melamine withdrawn plays a key role in the rapid regression of the stone and BEH. ► The BEH may be reversible and the conventional conservative therapy is reasonable.