Polyphenolic extract isolated from Korean Lonicera japonica Thunb. induce G2/M cell cycle arrest and apoptosis in HepG2 Cells: Involvements of PI3K/Akt and MAPKs

► Polyphenolic extract induce the G2/M cell cycle arrest in HepG2 cells. ► Polyphenolic extract control the expression level of cell cycle related proteins. ► Polyphenolic extract induce apoptosis by inhibition of PI3K/Akt and activation of MAPKs.