Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: A 26-week intramuscular repeated administration study in rats

► In this communication, the potential subchronic toxicity of Rg3 was investigated. ► A 26-week intramuscular toxicity study in rats was conducted. ► Rg3 was administrated to rats at dose levels of 0, 4.2, 10.0 or 20.0 mg/kg/day. ► The no-observed-adverse-effect levels for rats were considered to be 4.2 mg/kg/day.