Methyl helicterate protects against CCl4-induced liver injury in rats by inhibiting oxidative stress, NF-κB activation, Fas/FasL pathway and cytochrome P4502E1 level

► Methyl helicterate reduced NF-κB activation and inhibited inflammatory response. ► Methyl helicterate protected against Fas/FasL-mediated apoptosis. ► Methyl helicterate blocked CYP2El-mediated CCl4 bioactivation.