Antitumor and antimetastatic activities of grape skin polyphenols in a murine model of breast cancer

► The migration of 4T1 cells was inhibited by grape skin polyphenols. ► The migration inhibition was not a result of inhibited cell viability. ► The migration inhibition may be involved in blocking the PI3k/Akt and MAPK pathways. ► The pulmonary metastasis was inhibited and the survival of the mice enhanced.