کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5852692 1130852 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice
چکیده انگلیسی

Selenium (Se) is an essential trance element in testis. However, the potential protective effects of Se against cadmium (Cd)-induced reproductive toxicity remained to be elucidated. Male ICR mice were orally administered by gavage with Na2SeO3 (0.1, 0.2, 0.4 mg/kg BW) for 1 h prior to CdCl2 (5 mg/kg BW) alone or in combination for 15, 25 or 35 days. Cd exposure caused a significant decrease in body weight, sperm concentration and motility as well as plasma testosterone level which was accompanied by decreased antioxidant enzymatic activity of SOD and GSH-Px and by increased lipid peroxidation (as malondialdehyde, MDA). Se pretreatment compensated deficits in the sperm parameters (concentration, motility and morphology) induced by Cd. Se (0.4 mg/kg BW) treatment significantly increased serum testosterone level that was reduced by Cd (on 15th, 25th and 35th day) (P < 0.01). Se treatment ameliorated Cd-induced reduction in testicular steroidogenic acute regulatory (StAR) and 17β-hydroxysteroid dehydrogenase (17β-HSD) activities. The present study suggest that the protective potential of Se against Cd-induced reprotoxicity might be due to up-regulation StAR and testosterone synthetic enzyme activity, which could be useful for increasing testosterone synthesis for achieving optimum protection in sperm quality and spermatogenesis.

► We examine protection of Se pretreatment on Cd toxicity at three time points. ► Protection of Se on spermatogenesis is corroborated by FCM. ► Se ameliorates testosterone decrease induced by Cd. ► Se can activate StAR and testosterone synthetic enzymes activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 50, Issue 10, October 2012, Pages 3521-3529
نویسندگان
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