Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models

► HMGB1 is pro-inflammatory cytokine as a late mediator of inflammation. ► Lycopene inhibits LPS induced HMGB1 release. ► Lycopene inhibits and HMGB1 mediated inflammatory responses in cell and mice models. ► Lycopene also inhibits expressions of HMGB1 receptors.