Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats

► Glucocorticoids and β-amyloid peptides deposition are correlated with AD. ► It is unclear about the simultaneous effects of glucocorticoids and Aβ on neurons. ► DEX + Aβ25-35 can accelerate learning and memory impairments, increase APP processing. ► AST treatment can improve the learning and memory and decrease APP and Aβ expression. ► AST has protective effects on hippocampus neuronal injury induced by GCs + Aβ.