Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes

► Isothiocyanates activate Nrf2. ► Isothiocyanates are able to modulate cytochrome P450s (CYPs) antioxidant and phase II enzymes. ► Isothiocyanates have the potential to inhibit the bioactivation of carcinogens.