کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5853172 | 1130856 | 2011 | 7 صفحه PDF | دانلود رایگان |
Acute and 90-day subchronic oral toxicity studies of Silk peptide E5K6 were performed in Sprague-Dawley rats. In the acute toxicity study, Silk peptide E5K6 was administered orally to male and female rats at a single dose of 2000 and 5000Â mg/kg. Mortality, clinical signs and body weight changes were monitored for 14Â days. There were no treatment-related changes in these parameters. Therefore, the Approximate Lethal Dose (ALD) of Silk peptide E5K6 in male and female rats is higher than 5000Â mg/kg. In the subchronic toxicity study, Silk peptide E5K6 was administered orally to male and female rats for 90Â days at a single dose of 500, 1000, and 2000Â mg/kg. There were no toxicologically significant changes in clinical signs, body weight, food and water consumptions, ophthalmoscopic examination, urinalysis, hematological and serum biochemical examinations, necropsy findings, organ weights and histopathological examination of all of the animals treated with Silk peptide E5K6. These results suggest that the oral No Observed Adverse-Effect Level (NOAEL) of Silk peptide E5K6 is greater than 2000Â mg/kg/day in both sexes and the target organs were not established.
⺠We performed acute and 90-day subchronic oral toxicity studies of Silk peptide E5K6. ⺠Acute oral ALD of E5K6 was considered to be higher than 5000 mg/kg in rats. ⺠Subchronic oral NOAEL of E5K6 was considered to be higher than 2000 mg/kg in rats. ⺠The target organ was not identified in subchronic toxicity study.
Journal: Food and Chemical Toxicology - Volume 49, Issue 9, September 2011, Pages 2408-2414