کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5853215 1130858 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant and lipid peroxidation activities in rats fed with Aspergillus carbonarius carotenoid
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Antioxidant and lipid peroxidation activities in rats fed with Aspergillus carbonarius carotenoid
چکیده انگلیسی

Effect of feeding partially saturated canthaxanthin (PSC), purified from Aspergillus carbonarius mutant, was studied using four groups of female albino rats (n = 6) for 4 weeks. While the control group received basal diet ad libitum, Groups I, II and III were fed with basal diet containing 50, 100 and 250 ppm PSC, respectively. PSC feeding did not cause any significant changes in food intake and there was no gain in body weight either. PSC included in the diet significantly decreased cholesterol in blood. There was 44.75% and 60.54% decrease in LDL-cholesterol in rats fed with 50 and 100 ppm carotenoid. Hepatic ascorbic acid content increased by 44.59% in rats fed with 50 ppm PSC. Dietary PSC at 250 ppm lowered lipid peroxides by 19.49%. Activities of antioxidant enzymes, glutathione transferase and catalase were significantly higher in serum and liver of PSC fed rats compared to the controls. The results suggested that PSC feeding can induce hypocholesterolmic and antioxidant properties in rats.

► Serum total and LDL-cholesterol levels were influenced by the dietary carotenoid. ► Intake of PSC beneficially affected the hepatic ascorbic content and lipid peroxides. ► Glutathione transferase and catalase activities are enhanced in PSC treated rats. ► Study opens up a new research on antioxidant, hypocholesterolemic properties of PSC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 49, Issue 12, December 2011, Pages 3098-3103
نویسندگان
, , , , ,