Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: A literature review

► Effects of GM diets in all long-term and multigenerational studies were analyzed. ► No sign of toxicity in analyzed parameters has been found in long-term studies. ► No sign of toxicity in parameters has been found in multigenerational studies. ► The 90-day OECD Guideline seems adequate for evaluating health effects of GM diets. ► Benefits of harmonizing experimental protocols in fundamental research are discussed.