Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice

► Coleus forskohlii root extract (CFE) induced activities of hepatic drug metabolizing enzymes (CYPs and GST) in mice. ► CFE increased mRNA expression of CYPs and GST with dose related responses. ► Intake of two different sources of CFE showed similar response toward inductions of CYPs. ► Induction of CYPs by CFE was detected at 1 week of feeding and rapidly recovered after discontinuation. ► Forskolin was not involved in the marked induction of CYPs by CFE.