Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of androgen-independent human prostate cancer cell line, PC3

► Kuguacin J suppressed an androgen-independent human prostate cancer PC3 cell growth through G1-arrest. ► Kuguacin J inhibited PC3 invasion with reduction of MMP-2, MMP-9 and uPA secretions. ► Bitter melon leaf extract, which contains Kuguacin J, inhibited PC3 xenograft growth in vivo.