Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses

► HMGB1 is proinflammatory cytokine as a late mediator of inflammation. ► Kaempferol-3-O-sophoroside (KP) was isolated from mountain ginseng for the first time. ► KP inhibits LPS induced HMGB1 release. ► It also inhibits HMGB1 mediated inflammatory responses.