Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava

► Rats and mice were administered Kava Kava by gavage for two weeks, thirteen weeks or two years. ► Prechronic studies revealed dose-related increases in liver weights and hepatocellular hypertrophy. ► Dose-related increases in non-neoplastic lesions seen in rats and mice in chronic studies. ► Additionally, hepatocarcinogenecity seen in male and female mice with chronic exposure.