کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5853900 | 1130868 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety evaluation of Lactobacillus pentosus strain b240
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
IACUC9-AAGLPMCVL. pentosusAAALAC2-aminoanthraceneAF-2APTTLD50CFU2-AA - 2 AAA/G - A / GAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Association for Assessment and Accreditation of Laboratory Animal Care - انجمن ارزیابی و اعتباربخشی مراقبت از حیوانات آزمایشگاهیGood Laboratory Practice - تمرین خوب آزمایشگاهیMean corpuscular volume - حجم متوسط مایعactivated partial thromboplastin time - زمان ترومبوپلاستین جزئی فعال شده استInstitutional Animal Care and Use Committee - سازمان مراقبت و مراقبت از حیواناتcyclophosphamide monohydrate - سیکلوفسفامید مونوهیدراتLactobacillus pentosus - لاکتوباسیلوس پنتوسوسcolony forming units - واحدهای تشکیل دهنده کلنیbody weight - وزن بدن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Lactobacillus pentosus has a long history of use in cooked and uncooked fermented foods. Viable and heat-killed nonviable preparations of L. pentosus strain b240 were evaluated for short term and subchronic toxicity and genotoxic potential. Dose levels were determined through acute oral toxicity tests with viable (LD50 > 2500 mg/kg) and nonviable (LD50 > 2000 mg/kg) b240. In the short term study, rats received 2500 mg/kg/day (â¼1.7 Ã 1011 cfu/kg/day) viable b240 for 28 days. In the subchronic study, rats received 500, 1000 or 2000 mg/kg/day (up to â¼3.0 Ã 1012 cfu equivalents/kg/day) nonviable b240 for 91 days followed by a 28-day recovery. No mortalities occurred. No treatment-related effects were identified for general condition, body weight, food-water consumption, ophthalmology, urinalysis, hematology, blood chemistry, organ weights, histopathology and gross pathology. Although statistically significant effects were noted for several endpoints in the short term and subchronic studies, none were related to the test materials. The NOAEL for nonviable b240 was 2000 mg/kg/day, the highest dose tested. Additionally, nonviable b240 (⩽5000 μg/plate) was not mutagenic in Salmonella typhimurium or Escherichia coli tester strains nor did nonviable b240 orally administered to rats at levels ⩽ 2000 mg/kg/day for two days, induce a clastogenic response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 49, Issue 1, January 2011, Pages 251-258
Journal: Food and Chemical Toxicology - Volume 49, Issue 1, January 2011, Pages 251-258
نویسندگان
Nancy J. Szabo, Laurie C. Dolan, George A. Burdock, Takashi Shibano, Shin-ichi Sato, Hiroshi Suzuki, Tohru Uesugi, Satoko Yamahira, Masamichi Toba, Hirofumi Ueno,