کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5853928 | 1130869 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gestational and lactational transfer of melamine following gavage administration of a single dose to rats
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Melamine contamination in an infant formula manufactured by a firm in China was reported in September 2008. Maternal transfer of melamine during pregnancy and through breast-feeding are possible ways of introduction. This study aims to evaluate the maternal transfer of melamine into amniotic fluid and breast milk through oral intake by pregnant and lactating rats, respectively. The quantity of melamine in the dam's sera, amniotic fluid, breast milk as well as in fetal whole body extract was measured. Our results showed that, after administration of single dose of 21.4Â mg/kg per body weight of melamine to pregnant rats (16-18Â days of gestation) by gavage, about 80% of melamine was found in dam's serum in 0.5Â h. Melamine further reached the fetuses through placental transfer as it was found that peak melamine level of 7.15Â ppm (â¼30%) was detected in the fetuses after 2Â h and 4.36Â ppm (â¼20%) was shown in amniotic fluid after 3Â h of maternal intake. In the lactating rats, about 40% of maternal intake of melamine was transferred to breast milk and peaked at 3Â h. The results of this study confirmed the maternal transfer of melamine to fetuses in utero and infants through breast feeding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 49, Issue 7, July 2011, Pages 1544-1548
Journal: Food and Chemical Toxicology - Volume 49, Issue 7, July 2011, Pages 1544-1548
نویسندگان
Judy Yuet Wa Chan, Chau Ming Lau, Tai Lun Ting, Thomas Chung Wai Mak, Michael Ho Ming Chan, Christopher Wai Kei Lam, Chung Shun Ho, Chi Chiu Wang, Tai Fai Fok, Kwok Pui Fung,