کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5854446 1130901 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective role of vitamin E on nickel and/or chromium induced oxidative stress in the mouse ovary
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Protective role of vitamin E on nickel and/or chromium induced oxidative stress in the mouse ovary
چکیده انگلیسی
In the present study, we report the in vivo effects of nickel chloride (NiCl2; 8 and 16 mg/kg body weight) and/or potassium dichromate (K2Cr2O7; 5 and 10 mg/kg body weight) in the ovary of adult mice. The protective role of vitamin E (2 mg/kg body weight) along with their combination was also studied. Nickel and/or chromium to mice enhanced the levels of lipid peroxides in the ovary, which was accompanied by a significant decline in the levels of protein, glutathione, total ascorbic acid and activities of superoxide dismutase and catalase. Supplementation of vitamin E along with NiCl2 + K2Cr2O7 significantly lowered the levels of lipid peroxidation and enhanced the antioxidant status. Findings of the present study suggest that vitamin E exerts its protective effect against nickel and/or chromium induced toxicity by preventing lipid peroxidation and protecting antioxidant system in the mouse ovary.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 47, Issue 6, June 2009, Pages 1368-1371
نویسندگان
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