کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5871390 1142581 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Randomized control trialsEffects of vitamin D on plasma lipid profiles in statin-treated patients with hypercholesterolemia: A randomized placebo-controlled trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Randomized control trialsEffects of vitamin D on plasma lipid profiles in statin-treated patients with hypercholesterolemia: A randomized placebo-controlled trial
چکیده انگلیسی

SummaryBackground & aimsLipid abnormalities are regarded as a risk factor for cardiovascular disease. Low vitamin D status has been shown to be associated with hyperlipidemia. We planned to research the effects of vitamin D supplementation as an adjuvant therapy for patients with hypercholesterolemia.MethodsPatients with hypercholesterolemia were enrolled in this single-center, double-blind, placebo-controlled trial in Beijing (39°54′ N). Fifty-six patients were randomly assigned to receive vitamin D (n = 28, 2000 IU/d) or a placebo (n = 28) as an add-on to statin, by the method of permutated block randomization. Serum lipid levels were evaluated at baseline, 1, 3 and 6 months.ResultsVitamin D supplementation resulted in increased serum 25-hydroxyvitamin D concentrations compared with placebo (+16.3 ± 11.4 compared with +2.4 ± 7.1 ng/ml; p < 0.001). At 6 months, the primary end point, a difference in the fall of serum total cholesterol levels between the vitamin D and placebo groups after 6 months of treatment was significant −22.1 mg/dl (95% CI −32.3; −12.2) (p < 0.001). The difference between the groups in the fall of serum triglyceride levels after 6 months of treatment was −28.2 mg/dl (95% CI −48.8; −8.4) (p < 0.001). In patients with 25-hydroxyvitamin D level<30 ng/ml at baseline (n = 43), the serum total cholesterol and triglyceride levels were reduced by −28.5 ± 11.9 mg/dl (p < 0.001) and −37.1 ± 19.5 mg/dl (p < 0.001), respectively.ConclusionsVitamin D supplementation might improve serum lipid levels in statin-treated patients with hypercholesterolemia, it might be an adjuvant therapy for patients with hypercholesterolemia.Clinical Trials Registration Number - NCT02009787.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 34, Issue 2, April 2015, Pages 201-206
نویسندگان
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