کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5871626 1142617 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Randomized Controlled TrialsGlucomannan is not effective for the treatment of functional constipation in children: A double-blind, placebo-controlled, randomized trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Randomized Controlled TrialsGlucomannan is not effective for the treatment of functional constipation in children: A double-blind, placebo-controlled, randomized trial
چکیده انگلیسی

SummaryBackground & aimsTreatment measures for constipation in children are often not satisfactory. The aim was to assess the efficacy of glucomannan (GNN) as a sole treatment for functional constipation.MethodsChildren aged 3-16 years with functional constipation according to Rome III criteria were randomly assigned to receive GNN (2.52 g/d) or placebo for 4 weeks.ResultsOf the 80 children, 72 (90%) completed the study. The primary outcome, treatment success (≥3 stools per week with no soiling), was similar in the GNN (n = 36) and placebo (n = 36) groups (relative risk 0.95, 95% CI 0.6 to 1.4). In the GNN group, the stool consistency score was higher at week 1 (P < 0.0001), lower at week 3 (P = 0.008), and similar at weeks 2 and 4. Stool frequency was higher only at week 3 (P = 0.007). Abdominal pain episodes were more frequent in the GNN group at week 1 (P = 0.04) and week 4 (P < 0.0001) but were similar between groups at weeks 2 and 3. No difference was observed in the frequency of any other secondary outcome or adverse event.ConclusionsIn our setting, GNN, as dosed in this study, was not more effective than placebo in achieving therapeutic success in constipated children.The trial was registered at ClinicalTrials.gov (http://clinicaltrials.gov), number NCT01151878.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 30, Issue 4, August 2011, Pages 462-468
نویسندگان
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