Meta-analysesSystematic review and meta-analysis of randomised controlled trials testing the effects of vitamin C supplementation on blood lipids

SummaryBackground & aimsRandomised controlled trials (RCTs) in humans revealed contradictory results regarding the effect of vitamin C supplementation on blood lipids. We aimed to conduct a systematic review and meta-analysis of RCTs investigating the effect of vitamin C supplementation on total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and triglycerides and to determine whether the effects are modified by the participants' or intervention characteristics.MethodsFour databases (PubMed, Embase, Scopus and Cochrane Library) were searched from inception until August 2014 for RCTs supplementing adult participants with vitamin C for ≥ 2 weeks and reporting changes in blood lipids.ResultsOverall, vitamin C supplementation did not change blood lipids concentration significantly. However, supplementation reduced total cholesterol in younger participants (≤52 years age) (−0.26 mmol/L, 95% CI: −0.45, −0.07) and LDL-C in healthy participants (−0.32 mmol/L, 95% CI: −0.57, −0.07). In diabetics, vitamin C supplementation reduced triglycerides significantly (−0.15 mmol/L, 95% CI: −0.30, −0.002) and increased HDL-C significantly (0.06 mmol/L, 95% CI: 0.02, 0.11). Meta-regression analyses showed the changes in total cholesterol (β: −0.24, CI: −0.36, −0.11) and in triglycerides (β: −0.17, CI: −0.30, −0.05) following vitamin C supplementation were greater in those with higher concentrations of these lipids at baseline. Greater increase in HDL-C was observed in participants with lower baseline plasma concentrations of vitamin C (β: −0.002, CI: −0.003, −0.0001).ConclusionsOverall, vitamin C supplementation had no significant effect on lipid profile. However, subgroup and sensitivity analyses showed significant reductions in blood lipids following supplementation in sub-populations with dyslipidaemia or low vitamin C status at baseline.PROSPERO Database registration: CRD42014013487, http://www.crd.york.ac.uk/prospero/.