کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5871982 1564711 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articlePostprandial protein metabolism but not a fecal test reveals protein malabsorption in patients with pancreatic exocrine insufficiency
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Original articlePostprandial protein metabolism but not a fecal test reveals protein malabsorption in patients with pancreatic exocrine insufficiency
چکیده انگلیسی

SummaryBackground & aimsPancreatic exocrine insufficiency (PEI) impairs fat absorption, but few data are available on protein absorption. We investigated this question in patients with chronic pancreatitis, both in the absence and presence of enzyme therapy, using a stable isotope sensitive method.MethodsEleven patients with sustained PEI and regular enzyme substitution were investigated at hospital, after a washout period without enzyme substitution, and later after reintroduction of substitution. The digestibility and postprandial metabolism of dietary protein were characterized after the ingestion of a semi-synthetic single meal containing 20 g 15N-labeled casein.ResultsAt baseline, 20 ± 8% of dietary nitrogen was transferred to the metabolic pools vs. 24.5 ± 7% under enzyme treatment (P = 0.04). After treatment, the transfer of dietary nitrogen tended to increase in plasma amino acids, and increased significantly in plasma proteins and the deamination pool. In contrast, the fecal excretion of dietary nitrogen did not demonstrate any treatment effect. In patients not receiving insulin for diabetes, the treatment stimulated insulin secretion.ConclusionsProtein malabsorption was mostly undetectable using standard fecal tests. The study of the postprandial fate of dietary protein revealed a moderate increase of its transfer to metabolic pools after enzyme substitution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 30, Issue 6, December 2011, Pages 831-837
نویسندگان
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