کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5872110 1143002 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Opinion paperInflammation in cancer cachexia: To resolve or not to resolve (is that the question?)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Opinion paperInflammation in cancer cachexia: To resolve or not to resolve (is that the question?)
چکیده انگلیسی

SummaryBackground & aimsCachexia is associated with poor prognosis and shortened survival in cancer patients. Growing evidence points out to the importance of chronic systemic inflammation in the aetiology of this syndrome. In the recent past, chronic inflammation was considered to result from overexpression and release of pro-inflammatory factors. However, this conception is now the focus of debate, since the importance of a crescent number of pro-resolving agents in the dissolution of inflammation is now recognised - leading to the hypothesis that chronic inflammation occurs rather due to failure in the resolution process. We intend to put forward the possibility that this may also be occurring in cancer cachexia.MethodsRecent reviews on inflammation and cachexia, and on the factors involved in the resolution of inflammation are discussed.ResultsThe available information suggests that indeed, inflammation resolution failure may be present in cachexia and therefore we speculate on possible mechanisms.ConclusionsWe emphasise the importance of studying resolution-related mechanisms in cancer cachexia and propose the opening of a new venue for cachexia treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 31, Issue 4, August 2012, Pages 562-566
نویسندگان
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