کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5872565 1143204 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Randomized control trialsImmunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial
ترجمه فارسی عنوان
آزمایش های تصادفی کنترل بیماری های ایمونولوژیک تومورهای ایمنی بدن و ظرفیت دفاع آنتی اکسیدانی لکوسیت ها را در بیماران مبتلا به سرطان سر و گردن و مری تحت درمان با رادیوتراپی قرار می دهند: یک کارآزمایی بالینی تصادفی دو سو کور
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی

SummaryBackgroundImmunonutrition has been reported to improve the immune status of perioperative cancer patients, thereby reducing complications and length of hospital stay.AimThis study aimed to assess whether immunonutrition enriched in arginine, EPA & DHA and nucleotides could impact the immune cells responses in head & neck and esophageal cancer patients treated by radiochemotherapy (RCT).MethodsA double-blind clinical trial was carried out in 28 patients randomized into two groups, receiving either an immunomodulating enteral nutrition formula (IEN, n = 13, Impact®, Nestlé) or an isoenergetic isonitrogenous standard enteral nutrition formula (SEN, n = 15) throughout RCT (5-7 weeks). After isolation from whole blood, immune cells metabolism and functions were assessed at the beginning (Db) and at the end (De) of RCT.ResultsImmunonutrition maintained CD4+/CD8+ T-lymphocyte counts ratio and CD3 membrane expression between Db and De. Polymorphonuclear cells CD62L and CD15 densities and ROS production were increased in IEN patients. Peripheral blood mononuclear cells (PBMC) production of pro-inflammatory prostaglandin-E2 was stable in IEN patients and lower than in SEN patients at De. Genes coding for immune receptors, antioxidant enzymes and NADPH oxidase subunits were overexpressed in the PBMC of IEN vs SEN patients at De.ConclusionImmunonutrition can enhance immune cell responses through the modulation of their phenotypes and functions. By modulating the gene expression of immune cells, immunonutrition could make it easier for the organism to adapt to the systemic inflammation and oxidative stress induced by RCT.Clinical trial registration: This clinical trial has been registered on ClinicalTrial.gov website: NCT00333099.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Nutrition - Volume 34, Issue 5, October 2015, Pages 810-817
نویسندگان
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