کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5877949 1146127 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ArticleRespiratory Factors Contributing to Exercise Intolerance in Breast Cancer Survivors: A Case-Control Study
ترجمه فارسی عنوان
عوامل اصلی پارگی مجاری تنفسی در ناتوانی در ورزش در افراد سرطانی مبتلا به سرطان: مطالعه مورد شاهدی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

ContextBreast cancer survivors often experience activity-related dyspnea and exercise intolerance, but the underlying mechanisms remain unknown.ObjectivesWe evaluated physiological contributors to reduced peak oxygen uptake (VO2), with particular attention to the role of respiratory impairment.MethodsWe compared symptom assessments, respiratory and peripheral muscle strength, pulmonary function, and ventilatory responses to symptom-limited incremental treadmill exercise in 29 women who had survived breast cancer and 29 age-matched healthy controls.ResultsPeak VO2 was reduced more than 20%, on average, in the cancer group compared with controls (P < 0.001). Slopes of dyspnea intensity ratings over ventilation or VO2 were >50% greater in the cancer group compared to controls (P < 0.05). Women with breast cancer had lower lung diffusing capacity for carbon monoxide (DLCO), respiratory and limb muscle strength, and ventilatory thresholds during exercise compared with controls (all P < 0.05). During exercise, indices of ventilatory efficiency were similar to controls, but inspiratory capacity (IC) was lower and breathing pattern was more rapid and shallow in the cancer group (P < 0.05). The lower peak VO2 in the cancer group was associated with greater dyspnea intensity, and lower DLCO, IC and ventilatory threshold (all P < 0.05).ConclusionBreast cancer survivors had greater peripheral and respiratory muscle weakness, greater reduction of IC, impaired lung diffusion, and evidence of deconditioning compared with controls. Exercise intolerance was multifactorial and correlated well with the combination of these factors as well as with exertional dyspnea. Individualized physiological testing in breast cancer survivors can identify important contributors to exercise intolerance which can be targeted for treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pain and Symptom Management - Volume 52, Issue 1, July 2016, Pages 54-63
نویسندگان
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