Differential Roles of Peripheral Mitogen-Activated Protein Kinase Signal Transduction Pathways in Bee Venom-Induced Nociception and Inflammation in Conscious Rats

The present article showed that intraplantar injection of different MAPK inhibitors produced differential effects on bee venom-induced nociception and inflammation, suggesting that the peripheral MAPK signal transduction pathways have differential roles. Targeting specific peripheral MAPKs might prove effective in the treatment of persistent pain and inflammation.