Contralateral High or a Combination of High- and Low-Frequency Transcutaneous Electrical Nerve Stimulation Reduces Mechanical Allodynia and Alters Dorsal Horn Neurotransmitter Content in Neuropathic Rats

Because CCI rats are reminiscent of humans with neuropathy, daily high or a combination of high- and low-frequency TENS may reduce mechanical allodynia in humans with neuropathic pain. Because the 2 intervention strategies produce distinctive alterations in spinal cord neurotransmitter content, each may represent a distinctive option for treatment.