Lack of Muscle Contractile Property Changes at the Time of Perceived Physical Exhaustion Suggests Central Mechanisms Contributing to Early Motor Task Failure in Patients With Cancer-Related Fatigue

CRF patients perceive physical exhaustion sooner during a motor fatigue task with minimal muscular fatigue. The observation supports that central fatigue is a more significant factor than peripheral fatigue in causing fatigue feelings and limits motor function in cancer survivors with fatigue symptoms.