کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5882831 1149769 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original StudyAcute Myeloid Leukemia With t(10;11): A Pathological Entity With Distinct Clinical Presentation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Original StudyAcute Myeloid Leukemia With t(10;11): A Pathological Entity With Distinct Clinical Presentation
چکیده انگلیسی

IntroductionAcute myeloid leukemias with MLL rearrangements are frequently associated with myelomonocytic and monoblastic/monocytic morphology, with an increased risk of leukocytosis and leukostasis-related complications. Yet, little is known regarding the clinical presentation of adult AML patients with MLL translocations based on the specific translocation partner.Patients and MethodsTwo recent AML cases with t(10;11)(p12;q23) translocations are detailed, with their shared presenting symptoms highlighted, followed by a review of the current literature.ResultsThe specific t(10;11)(p12;q23) MLL translocation is a rare recurrent translocation partner, most commonly seen in pediatric and young adult AML. A high incidence of early morbidity from leukocytosis-related complications are frequently seen, including diffuse intravascular coagulation and tumor lysis syndrome with multiorgan system failure, even without a true leukocytosis.ConclusionWith prompt therapy and intensive supportive care first remissions are frequently attained, however, patients have a high risk of relapse, extramedullary disease, and poor long-term outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lymphoma Myeloma and Leukemia - Volume 15, Issue 1, January 2015, Pages 47-51
نویسندگان
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