کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5885924 1150928 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of acute endotoxemia on analog estimates of mean systemic pressure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Effect of acute endotoxemia on analog estimates of mean systemic pressure
چکیده انگلیسی

Dynamic estimates of mean systemic pressure based on a Guytonian analog model (Pmsa) appear accurate under baseline conditions but may not remain so during septic shock because blood volume distribution and resistances between arterial and venous beds may change. Thus, we examined the effect of acute endotoxemia on the ability of Pmsa, estimated from steady-state cardiac output, right atrial pressure, and mean arterial pressure, to reflect our previously validated instantaneous venous return measure of mean systemic pressure (Pmsi), derived from beat-to-beat measures of right ventricular stroke volume and right atrial pressure during positive pressure ventilation. We studied 6 splenectomized pentobarbital-anesthetized close chested dogs. Right ventricular stroke volume was measured by a pulmonary arterial electromagnetic flow probe. Instantaneous venous return measure of mean systemic pressure and Pmsa were calculated during volume loading and removal (± 100-mL bolus increments × 5) both before (control) and 30 minutes after endotoxin infusion (endo). Cardiac output increased (2628 ± 905 vs 3560 ± 539 mL/min; P < .05) and mean arterial pressure decreased (107 ± 16 vs 56 ± 12 mm Hg; P < .01) during endo. Changes in Pmsi and Pmsa correlated during both control and endo (r2 = 0.7) with minimal bias by Bland-Altman analysis (mean difference ± 95% confidence interval, 0.47 ± 5.04 mm Hg). We conclude that changes in Pmsa accurately tracts Pmsi under both control and endo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Critical Care - Volume 28, Issue 5, October 2013, Pages 880.e9-880.e15
نویسندگان
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