کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5886661 1150940 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of hemodialysis on blood glutamate levels in chronic renal failure: Implementation for neuroprotection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
The effects of hemodialysis on blood glutamate levels in chronic renal failure: Implementation for neuroprotection
چکیده انگلیسی

PurposeThe purpose of the present study is to investigate whether hemodialysis (HD) is effective in lowering blood glutamate levels. In addition, we examined the effect of HD on glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels in the blood and described the rate and pattern of blood glutamate clearance during HD.Materials and MethodsBlood samples were taken from 45 patients with stage V chronic kidney disease immediately after initiation of HD and hourly, for a total of 5 blood samples. Samples were sent for determination of glutamate, glucose, GOT, GPT, hemoglobin, hematocrit, urea, and creatinine levels. A blood sample from 25 healthy volunteers without chronic renal failure was used as a control for the determination of baseline blood levels of glutamate, GOT, and GPT.ResultsGlutamate and GPT levels in patients on HD were higher at baseline compared with healthy controls (P < .001). In the first 3 hours after HD, there was a decrease in blood glutamate levels compared with baseline levels (P < .00001). At the fourth hour, there was an increase in blood glutamate levels compared with the third hour (P < .05).ConclusionsHemodialysis may be a promising method of reducing blood glutamate levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Critical Care - Volume 27, Issue 6, December 2012, Pages 743.e1-743.e7
نویسندگان
, , , , , , , , , , , , , ,