کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5887961 | 1567882 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ketamine - More mechanisms of action than just NMDA blockade
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
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چکیده انگلیسی
Ketamine has been in clinical use for over half a century, yet its precise mechanisms of action remain mysterious for the large part. Its hypnotic effects appear to be largely mediated by blockade of NMDA and HCN1 receptors, but cholinergic, aminergic, and opioid systems appear to play both a positive and negative modulatory role in both sedation and analgesia. Ketamine's effects in chronic pain, and as an antidepressant, far outlast the actual drug levels, and are probably mediated by a secondary increase in structural synaptic connectivity that is mediated by a neuronal response to the ketamine-induced hyper-glutamatergic state.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Anaesthesia and Critical Care - Volume 4, Issues 2â3, June 2014, Pages 76-81
Journal: Trends in Anaesthesia and Critical Care - Volume 4, Issues 2â3, June 2014, Pages 76-81
نویسندگان
Jamie Sleigh, Martyn Harvey, Logan Voss, Bill Denny,