کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5888433 | 1568018 | 2015 | 8 صفحه PDF | دانلود رایگان |
The steady state compositions of omega-6 and omega-3 polyunsaturated fatty acids (PUFA) throughout the various viscera and tissues within the whole body of rats have not previously been described in a comprehensive manner. Dams consumed diets containing 10 wt% fat (15% linoleate and 3% α-linolenate). Male offspring (n=9) at 7-week of age were euthanized and dissected into 25 compartments. Total lipid fatty acids for each compartment were quantified by GC/FID and summed for the rat whole body; total nâ6 PUFA was 12 wt% and total nâ3 PUFA was 2.1% of total fatty acids. 18:2nâ6 accounted for 84% of the total nâ6 PUFA, 20:4nâ6 was 12%, 18:3nâ3 was 59% of the total nâ3 PUFA, 20:5nâ3 was 2.1%, and 22:6nâ3 was 32%. The white adipose tissue contained the greatest amounts of 18:2nâ6 (1.5 g) and 18:3nâ3 (0.2 g). 20:4nâ6 was highest in muscle (60 mg) and liver (57 mg), while 22:6nâ3 was greatest in muscle (46 mg), followed by liver (27 mg) and carcass (20 mg). In terms of fatty acid composition expressed as a percentage, 18:2nâ6 was the highest in the heart (13 wt%), while 18:3nâ3 was about 1.3 wt% for skin, white adipose tissue and fur. 20:4nâ6 was highest (21-25 wt%) in the circulation, kidney, and spleen, while 22:6nâ3 was highest in the brain (12 wt%), followed by the heart (7.9 wt%), liver (5.9 wt%), and spinal cord (5.1 wt%). Selectivity was greatest when comparing 22:6nâ3 in brain (12%) to white adipose (0.08%) (68-fold) and 22:5nâ6 in testes (15.6%) compared to white adipose (0.02%), 780-fold.
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 100, September 2015, Pages 13-20