کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5888619 | 1568040 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fatty acid transport across the cell membrane: Regulation by fatty acid transporters
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کلمات کلیدی
AMPKCPTACSGLUT4FATPFABPpmFABPcacyl-CoA synthetase - Acyl-CoA Synthetaseplasma membrane fatty acid-binding protein - پروتئین اتصال دهنده اسید چرب غشاء پلاسماFatty acid transport protein - پروتئین حمل و نقل اسید چربCarnitine palmitoyltransferase - کارنتین پالمیتیل ترانسفرازAMP-activated kinase - کیناز فعال AMPglucose transporter-4 - گلوکز حمل کننده-4
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Transport of long-chain fatty acids across the cell membrane has long been thought to occur by passive diffusion. However, in recent years there has been a fundamental shift in understanding, and it is now generally recognized that fatty acids cross the cell membrane via a protein-mediated mechanism. Membrane-associated fatty acid-binding proteins ('fatty acid transporters') not only facilitate but also regulate cellular fatty acid uptake, for instance through their inducible rapid (and reversible) translocation from intracellular storage pools to the cell membrane. A number of fatty acid transporters have been identified, including CD36, plasma membrane-associated fatty acid-binding protein (FABPpm), and a family of fatty acid transport proteins (FATP1-6). Fatty acid transporters are also implicated in metabolic disease, such as insulin resistance and type-2 diabetes. In this report we briefly review current understanding of the mechanism of transmembrane fatty acid transport, and the function of fatty acid transporters in healthy cardiac and skeletal muscle, and in insulin resistance/type-2 diabetes. Fatty acid transporters hold promise as a future target to rectify lipid fluxes in the body and regain metabolic homeostasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 82, Issues 4â6, AprilâJune 2010, Pages 149-154
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 82, Issues 4â6, AprilâJune 2010, Pages 149-154
نویسندگان
Robert W. Schwenk, Graham P. Holloway, Joost J.F.P. Luiken, Arend Bonen, Jan F.C. Glatz,