کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5895961 | 1154498 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Mathematical Model of Intervillous Blood Flow in the Human Placentone
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute concentration distributions, which are illustrated for a range of governing system parameters. The model shows how the calibre of the basal vessels can be a dominant determinant of the maternal blood flow rate through the placentone, given a driving pressure difference between the spiral arteries and decidual veins. The model supports the hypothesis that basal veins are located on the periphery of the placentone in order to optimise delivery of nutrients and suggests the existence of an optimal volume fraction of villous tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 31, Issue 1, January 2010, Pages 44-52
Journal: Placenta - Volume 31, Issue 1, January 2010, Pages 44-52
نویسندگان
I.L. Chernyavsky, O.E. Jensen, L. Leach,