کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5896597 1568724 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of promising plasma immune biomarkers to differentiate active pulmonary tuberculosis
ترجمه فارسی عنوان
شناسایی بیومارکرهای امیدوار کننده ایمنی پلاسما برای تشخیص سل ریوی فعال ریه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- Active tuberculosis patients have increased plasma levels of IL-6, IP-10, TNF-α, sCD163 and sCD14.
- Simultaneous detection of plasma sCD14 and IL-6 can identify active tuberculosis with an accuracy of 83%.
- Plasma levels of sCD163 and TNF-α in APTB patients can classify the degree of disease progression.

Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarkers detected in plasma. Our study measured 18 molecules in human plasma in 17 patients with active disease (APTB), 14 individuals with latent tuberculosis infection (LTBI) and 16 uninfected controls (CTRL). We found that active tuberculosis patients have increased plasma levels of IL-6, IP-10, TNF-α, sCD163 and sCD14. Statistical analysis of these biomarkers indicated that simultaneous measurement of sCD14 and IL-6 was able to diagnose active tuberculosis infection with 83% accuracy. We also demonstrated that TNF-α and sCD163 were correlated with tuberculosis severity. We showed that the simultaneous detection of both plasma sCD14 and IL-6 is a promising diagnostic approach to identify APTB, and further, measurement of TNF-α and sCD163 can identify the most severe cases of tuberculosis.

118

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 88, December 2016, Pages 99-107
نویسندگان
, , , , , , , , , , ,