کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5896838 | 1568734 | 2016 | 7 صفحه PDF | دانلود رایگان |

- Influence of cytokine gene polymorphism in the outcome of stem cell transplantation is reported here.
- IL2 +166âT allele seems to be protective from cGVHD.
- IL10 â819 genotypes are associated with the risk of developing cGVHD.
- Patients who received donor stem cells with IL12 â1188âC allele are found to be associated with better disease free survival.
Non-HLA gene polymorphisms have been shown to be associated with the risk of graft-versus-host disease (GVHD) and outcome of allogeneic haematopoietic stem cell transplantation (AHSCT). This study aims to investigate the role of IL6, TNFα, IL10, IL2 and IL12 gene polymorphisms in the outcome of AHSCT in a South East Asian population. A total of 67 patients and 59 donors who underwent HLA-identical matched sibling AHSCT were available for analysis. There was no significant association between the different cytokine genotypes of patients with the incidence and severity of acute GVHD. Patients with IL2 166âT allele and patients who received donor stem cells who had IL2 166âG allele appeared to have reduced incidence of cGVHD. Patients who received donor stem cells with IL12 1188âC allele are found to be associated with better disease free survival. These results suggest a possible role of IL2 and IL12 gene polymorphisms in the outcome of AHSCT in a South East Asian population.
Journal: Cytokine - Volume 78, February 2016, Pages 55-61