کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5896847 1568734 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationInflammatory cytokines regulate secretion of VEGF and chemokines by human conjunctival fibroblasts: Role in dysfunctional tear syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Short communicationInflammatory cytokines regulate secretion of VEGF and chemokines by human conjunctival fibroblasts: Role in dysfunctional tear syndrome
چکیده انگلیسی


- Inflammatory cytokines enhance secretion of angiogenic molecules by HCJVF.
- Inflammatory cytokines did not affect secretion of anti-angiogenic molecules.
- Inflammatory cytokines induce IFN-γ inducible chemokines CXCL9, -10 and -11.
- Elevated levels of VEGF and chemokines contribute to the pathogenesis of DTS.

Ocular surface inflammation is one of the primary mechanisms associated with dysfunctional tear syndrome (DTS), also known as dry eye disease. DTS, more prevalent in older populations, causes ocular discomfort and visual disturbance due to dryness on the surface layer in the eye. We used human conjunctival fibroblast cultures (HCJVF) to investigate the effects of inflammatory cytokines IFN-γ, TNF-α and IL-1β (ITI) on the secretions of VEGF and chemokines. Our results demonstrate the elevated secretion of angiogenic VEGF molecules by ITI without affecting anti-angiogenic molecules, PEDF, endostatin, thrombospondin and sVEGF-R1. The secretion of interferon-γ inducible chemokines, CXCL9, -10, -11 by HCJVF were significantly enhanced by ITI. Our in vitro study supports previously reported observations of elevated VEGF and chemokines in tear fluids of DTS patients, reiterating the role of inflammatory reactions in DTS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 78, February 2016, Pages 16-19
نویسندگان
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