Expression of IL-32 modulates NF-κB and p38 MAP kinase pathways in human esophageal cancer

► We examine changes in the level IL-32 in normal and esophageal cancer tissue. ► IL-32 expression stimulate the secretion cytokines. ► c activate NF-κB and up-regulation of p-p38MAPK. ► IL-32 could be considered not solely as a therapeutic target in esophageal cancer. ► IL-32 expression may be used as a valid biomarker for disease progression.