Calcitriol downregulates TNF-α and IL-6 expression in cultured placental cells from preeclamptic women

► Calcitriol downregulated TNF-α expression in placentas from preeclamptic mothers. ► Calcitriol downregulated IL-6 expression in placentas from preeclamptic mothers. ► TNF-α, IL-6 and IL-1 expression decreased during trophoblast differentiation.