Ingested (oral) thyrotropin releasing factor (TRH) inhibits EAE

► Proteins by the oral route can have immuno-activity. ► Thyrotropin releasing factor (TRH) has intrinsic immuno-activity. ► Murine experimental autoimmune encephalomyelitis is an animal model for human disease multiple sclerosis. ► Thyrotropin releasing factor (TRH) administered orally inhibits murine experimental autoimmune encephalomyelitis. ► Adoptive transfer of lymphocytes from TRH fed donors into immunized recipients inhibits EAE.