Lack of association between IL27 gene variants and type 1 diabetes susceptibility

► The contribution of IL27 to human type 1 diabetes susceptibility was evaluated. ► IL27 was genotyped in 318 T1D patients and 296 healthy controls. ► Eight allelic variants, including two new ones, were identified. ► IL27 allelic variants did not predispose to type 1 diabetes in a Brazilian cohort. ► The frequency of estimated haplotypes was also similar between groups.