The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance

► Exercise prevents the development of insulin resistance through IL-6 to a certain degree. ► The secretion of IL-6 can improve the development of insulin resistance. ► IL-6 improved the development of IR possibly through elevating adiponectin. ► IL-6 improved the development of IR possibly through inhibiting STAT3. ► IL-6 improved the development of IR possibly through p38MAPK signal pathway.