Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children

► Obesity is associated with a chronic low inflammatory state. ► Genetic factors associated with obesity are also associated with serum monocyte chemoattractant protein-1 (MCP-1) levels. ► A GWAS in obese Hispanic children showed strong association between DARC gene and serum MCP-1 levels. ► Serum MCP-1 concentration was also significantly associated with CCR3 and CARD9 genes. ► The association of DARC with serum MCP-1 levels replicates previous GWAS results.